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Selank is a synthetic anxiolytic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is a synthetic analogue of the endogenous immunomodulatory peptide tuftsin, with added stabilising C-terminal residues. Like Semax, it is a registered medication in Russia, used clinically for generalised anxiety disorder and neurasthenia. Selank's key research distinction is its ability to produce anxiolytic effects comparable in magnitude to benzodiazepines without sedation, cognitive impairment, or dependence potential.

Molecular Data

Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro | Molecular Formula: C33H57N11O9 | Molecular Weight: 751.87 g/mod | CAS Number: 129954-34-3

GABAergic Anxiolytic Mechanism

Selank modulates GABAergic neurotransmission in a manner that produces anxiolytic effects without the receptor downregulation and dependence associated with benzodiazepines. Research suggests Selank potentiates GABA-A receptor function and normalises GABAergic tone under conditions of stress-induced disruption, producing anxiety reduction without the rebound anxiety or withdrawal phenomena observed with conventional GABAergic anxiolytics.

BDNF and Neuroplasticity

Like Semax, Selank upregulates BDNF expression in the hippocampus and prefrontal cortex, contributing to neuroplastic adaptations that underlie its long-lasting anxiolytic and cognitive effects. BDNF upregulation also supports neurogenesis in the dentate gyrus, which is suppressed by chronic stress and restored by effective anxiolytic treatments. This neuroplastic mechanism distinguishes Selank from conventional anxiolytics that do not address the underlying neurological consequences of chronic stress.

Immunomodulatory Properties

As a tuftsin analogue, Selank retains immunomodulatory properties — stimulating T-lymphocyte activity, natural killer cell function, and IL-2 production. Research demonstrates that Selank normalises disrupted immune function in stressed animals, providing evidence for a shared regulatory mechanism between the stress-anxiety system and immune function. This bidirectional modulation of stress and immunity makes Selank a valuable research tool in psychoneuroimmunology.

Neurotransmitter System Effects

Selank normalises stress-induced disruptions in serotonin, dopamine, and noradrenaline metabolism. In animal models of chronic stress, Selank restores neurotransmitter homeostasis, improving behavioural measures of anxiety, depression-like behaviour, and cognitive performance. These broad neurochemical effects suggest Selank acts as a neuromodulator rather than a receptor-specific drug, producing regulatory normalisation rather than pharmacological override.

Future Research

Selank research continues in models of anxiety, PTSD, depression, immune dysregulation, and cognitive ageing. Its clean safety profile in Russian clinical use, combined with its unique dual anxiolytic and immunomodulatory mechanism, positions it as an interesting research compound for conditions at the interface of stress and immune function.

Selank 10mg